Geldanamycins Trigger a Novel Ron Degradative Pathway, Hampering Oncogenic Signaling*
نویسندگان
چکیده
منابع مشابه
Geldanamycins trigger a novel Ron degradative pathway, hampering oncogenic signaling.
Ron, the tyrosine kinase receptor for macrophage-stimulating protein is responsible for proliferation and migration of cells from different tissues. Ron can acquire oncogenic potential by single point mutations in the kinase domain, and dysregulated Ron signaling has been involved in the development of different human cancers. We have previously shown that ligand-activated Ron recruits the nega...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2006
ISSN: 0021-9258
DOI: 10.1074/jbc.m602014200